Dissertation is devoted to the improvement of methods of treatment of feet mycosis and onychomycosis in elderly people taking into account age, clinical of peculiarity of the disease and mycologic tests, attendant pathology, findings which characterize immunity state, functional activity of the vascular system. In the group of the examined patients without feet mycosis, the depression of T-link of immunity (decrease of CD3+.CD4+, CD56+.CD16+) and IgG, depression of non-specific protective factors, RBTL was determined. This may be a background for fungi occurence. In the group of patients adequate in composition, but with feet mycosis all above-listed findings aggravated, a level circulating immune complexes (CIC), neutrophiles and monocytes sharply increased, a count of Ig G was decreasing with a further depression of NST-test, complement titre. In the main group of the patients examined with attendant marked somatic pathology, feet mycosis and onychomycosis and with sufficiently low initial immunity level, as in the previous groups, phagocytosis, complementary blood activity sharply depressed, a count of IgG and IgM decreased. Reovazographia of feet is showing decrease of filling of vessels by blood, increase of vascular resistance and elasticity of vessels of large caliber, and also slowing down of vein outflow, which wore researches more expressed at the patients of the basic group.The investigations performed made it possible to recommend a differential usage of lamisil or oxifin in dermatomycetic infection, orungal - in combined one and to use pathogenetic agents for the correction of immune status (cyklopheron), to better peripheral blood circulation and tissue trophisc (nicospan, solkoseril, aevit, ascorutin), for correction of alimentary tract activity (alochol, festal, kreon) and for the first time to ground scientifically and to introduce vita-melatonin. For the first time it is proposed to use antifungal laquer (benzoic acid, salicylic acid, undecylic acid, grizeofulvin, dimexid, glue BF-6) forthe external nails treatment (glue is produced ex tempore). After the conducted system antifungal treatment in 82,4 % patients are registered etiologic convalescence against 28,2 % - at patients which used external therapy antifungal only, at reduction of terms of treatment by 0,5-1 months at good good drug tolerance and absence of side effects, by the favourable changes of indexes of functional and immunologic researches; in 6 months the relapse; are registered in 6 patients, and through 1-1,5 years — in 11 patients.
