Gamma T. Effect of benzimidazole and its derivatives on electrical neuronal activity of Helix albescens Rossm. and rat behavior

The dissertation studies direction, concentration dependence and mechanisms of bezimidazole and its new derivatives effect on electrical processes in Helix albescens Rossm. neurons and their influence on rat behavior. These compounds occurred to have neurotropic properties dependant on their chemical structure and types of neurons. Threshold, optimal and toxic concentration values of the tested substances determined. Benzimidazole and 2- trifluoromethylbenzimidazole influence in concentrations of 10-3 and 10-2 М turned to render both excitatory and inhibitory postsynaptic potentials on soma membrane of some pacemaker and non-pacemaker neurons and even its strong depolarization. Pacemaker neurons membrane (namely, neuron RPа2) occurred to have at least two spatially separated trigger sites with different action potential trigger mechanism. After single intraperitoneal injection (50 mg/kg) of the substance solution, as a result of discovered effects the tested compounds were divided into two groups. Thefirst group inhibits locomotion and psychoemotional state of rats, the second group renders the opposite effect. Dosage of 100 and 150 mg/kg of all the tested substances appeared to inhibit animal's activity.