Ispiryan M. Pathogenetic mechanism interaction and complex corregated therapy of immunity system and intestinal microbiocenosis in patients with psoriasis

Dissertation is devoted to studying of peculiarities of pathogenic interaction of intestinal microbiocenosis and immunity system and also to caring out of method of differential correction of revealed disturbances in patients with psoriasis. It was revealed intestinal dysbacteriosis of the I-III degree in 86,2% patients with psoriasis, which manifestation are disturbances of specific structure and population level of microflora of large intestine cavity. It was determined that patients with psoriasis with intestinal dysbacteriosis were expressed dysfunction of systemic opsonocytophagic mechanism which is revealed by increase of NST-test activity (p < 0,05) and by reduction of plasmic fibronectin level (p < 0,001). And also dysimmunoglobulinemia has place, characterized by increase of Ig A (p < 0,001), Ig G (p < 0,001) levels and by reduction of Ig M (p < 0,01) level. Autoimmune processes with psoriasis with intestinal dysbacteriosis are characterized by authentic increase of autoantibodies Ig G (p < 0,01) and Ig M (p < 0,001) levels to unifiliform DNA and increase of autoantibodidies Ig G (p < 0,001) and Ig M (p < 0,05) levels to bifiliform DNA. Analysis of humoral antiendotoxinous immunity has revealed the increase of antiendotoxinous antibodies to lipopolysaccharides of E. coli class Ig A (p < 0,001), Ig M (p < 0,001), Ig G (p < 0,05) in patients with psoriasis with intestinal dysbacteriosis. It was carried out and instilled in Public health practice a method of patients' treatment with use of immunocorrector cyclopheron, probiotic biosporin and enterosorbent ultrasorb. Prescription of complex treatment to patients with psoriasis with intestinal dysbacteriosis allowed to achieve a positive clinical effect in 91,2 % patients, to contract a term of treatment in 1,3 times, to reduce a member of relapses in 2,2 times in comparative with traditional therapy.