Zharikov M. Morphofunctional condition of the secretory components of normal heart and under action of different factors

Dissertation work is devoted to the study of secretory components of normal human and rat heart and secretory components of rat heart in the model of hemodynamic overload of myocardium, and adrenalin and dexametazon treatment. The age morphological features and distribution of cardiac tissue mast cells and myoendocrine cells in the heart of people of mature period were determined. It has been shown that the hemodynamic overload of myocardium activates the secretory components of heart specific secretory granules. It was determined that adrenalin activates tissue mast cells and myoendocrine cells, dexametazon activates myoendocrine cells and retards the activity of tissue mast cells. We propose our own method of design of hemodynamic overload of myocardium and activation of secretory components of heart.