Petelkaki А. Pathogenetical peculiarities of experimental brain trauma under conditions of cytokine and dophaminergic systems modulation

In experiments on the model of brain trauma of average level of severity the dynamics of locomotor disturbances and parameters of immunological reactivity, namely T-lymphocytes function, immunoglobulines, tumor necrosis factor-alpha, blasttransformation reaction, morphometric parameters of stress- responsible organs as well as antioxidant mechanisms have been investigated. The heightened susceptibility of hippocampal structures to action of agonists of receptors of excitatory aminoacids-kainic acid and NMDA was established in posttraumatic period. The intensification of behavioral and immunological disturbances under conditions of decreasing of functional state of brain dophaminergic system in-duced via destruction of middle brain component was revealed. The protective effects of pentoxyphilline upon trauma- induced distur-bances and potentiation of it’s activity by L-deprenyl have been also established.