Object of the study: Thrombotic complications in pregnant and puerpera. Purpose of the study: To reduce the incidence of thrombotic complications in pregnant and puerpera based on development and introduction of scientifically substantiated program of prognosis and prevention of this pathology. Methods of the study: Clinical, hemostatic, hormonal, immuno-logical, morphological, instrumental, statistical. Practical significance: Revealing of the risk group among preg-nant and puerpera, the use of the developed methods of prognosis and the new schemes of preventive treatment will allow to optimize management of pregnancy, delivery and postnatal period in the pa-tients with the risk of thrombi. Introduction to the practice of the developed methods of prognosis and prevention of thrombi pro-motes reduction of maternal and perinatal morbidity and mortality caused by this pathology. Novelty of the obtained results: For the first time, point scale of assessment of thromboembolic complications of pregnancy wassuggested. The scale includes clinical characteristics of the course of pregnancy, duration, and character of delivery. Three degrees of risk were distinguished: mild (1) < 6 points, medium (2) 6-11 points, severe > 11 points, which allow to individualize the admini-stration of preventive measures. For the first time, it was established that in pregnant with the risk of thromboembolic complications, soluble monomer-fibrin complexes and D-dimers were sensitive prognostic markers. Their elevation 2-2.5 times suggests the necessity of including the patient to the risk group and administration of antithrombotic therapy. It was established that scientifically substantiated method of prognosis and prevention of thrombosis by means of complex nonspecific therapy and correction of the system of hemostasis and immunity allows to improve the blood rheology in the vessels of the small pelvis and lower extremities as well as to prolong remission of the autoimmune process and the course of viral diseases, which considerably reduces the risk of thromboembolic complications. Introduction: The findings of the research were introduced to the work of Donetsk Regional Center for Protection of Maternity and Childhood, Research Institute of Medical Problems of the Family, gynecology departments and outpatient maternity departments of city hospitals No. 3, 6, 17, 21 (Donetsk). The obtained findings are used in the teaching process at department of obstetrics, gynecol-ogy and perinatology of faculty for post-graduate training of Donetsk State Medical University named after M. Gorky Sphere of application: Medicine, obstetrics and gynecology.
