. Object of the study: varicose disease (VD) of lower extremity veins in pregnant women. Purpose of the study: improvement of early diagnosing of changes in the fetoplacental complex (FPC) and elaboration of medical-prophylactic measures in pregnant women with VD of lower extremity veins for reducing perinatal and maternal morbidity. Methods of the study: biochemical, immunoenzyme and histomorphological methods of investigation, apparatus techniques: ultrasonic visualization, dopplerometry, cardiotocography, pulsoximetry. Practical significance: the conducted investigations resulted in perfection of the algorithm of examination of pregnant women aimed at early diagnosis of subclinical forms of haemorheological and dyscirculatory disorders during gestation, assessment of the efficacy of their pharmacological correction. In order to prevent thrombembolic, dyscirculatory and coagulopathic complications in VD in pregnant women and those in labour, it was suggested to use Detralex venotonic drug preparation, with the daily dose of 500 mg by two divided doses during 8 weeks with a transfer to a maintenance dose of 500 mg/day up to the moment of childbirth in combination with elastic compression. Such a tactics of management makes it possible to decrease the total coefficient of gestational complication rate (anaemia, preeclampsia, a thread of interruption of pregnancy, chronic foetal hypoxia) on an average by the factor of two, thereby producing a favourable effect on the subsequent course of labour (absence of coagulopathic complications) and the state of a newborn child. Novelty of the obtained results: risk factors were revealed which facilitate development and progression of VD of lower extremity veins and should be used for prognosticating the disease and planning medical measures. For the first time, an integral assessment was made for the state of haemodynamics in the lower extremity veins and FPC, peculiarities of haemostasis and endocrine regulation of the reproductive function, the state of the intrauterine foetus, morphological changes in the placenta in VD of lower extremity veins of pregnant women. For the first time, it was found out that presence of VD of lower extremity veins in women served as a reliable aggravating factor capable of producing a systemic unfavourable effect on the state of the mother-placenta-foetus system (positive correlation, r = 0.635) and facilitating development of dyscirculation with unrevealed (by dopplerometric data) or clinically manifested signs of faetoplacental insufficiency in 32.1 % of cases. For the first time, morphological and immunohistochemical changes of placentae in VD of lower extremity veins were revealed. The rationality of administering De-tralex in combination with the method of elastic compression of the lower extremities was proved, it increasing the efficacy of the prevention and treatment of haemorheological and dyscirculatory complications of gestation by 12 %. Introduction: the obtained data concerning treatment of pregnant women with VD were introduced into the work of the Kharkiv Re-gional Hospital, Maternity Homes Nos 1 & 5 of the City of Kharkiv, Balakleya Central District Hospital, Valky Central Dis-trict Hospital. The theoretical propositions and practical recom-mendations are used in the teaching process of the Departments of Obstetrics and Gynaecology of Kharkiv State Medical University when studying relevant sections of obstetrics-gynaecology. Sphere of application: medicine, obstetrics and gynaecology.
