Pobelensky O. Experimental study of application efficiency of pancreas microfragments' cryopreserved culture in model alloxan diabetes in rats.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0407U003396

Thesis Registration Form

0407U003396.pdf

Applicant for

Pobelensky Oleg Nikolayevych

Specialization

14.01.35 - Кріомедицина

Date of defense

19-06-2007

Specialized Academic Board

Д 64.242.01

Institute of Cryobiology and Cryomedicine, National Academy of Sciences of Ukraine

Essay

The dissertation is aimed to investigate the application efficiency of cryopreserved culture of new born piglets' pancreas microfragments in rats with alloxan diabetes depending on introduction location:into parapancreatc tissue, under liver capsule, into liver, into spleen, intramuscularly. There was found localization of biological material introduction: into parapancreatic tissue that contributes to the most manifested clinical effect. The ability of cryopreserved xenogeneic pancreas microfragments has been shown to preserve the ability of produсіng insuline under biological material culturing in vitro and after in vivo use. Cryopreserved culture of new born piglets' pancreas microfragments has been found as causing а manifested positive effect on clinical course of pathological process, contributing to the recovery of carbohydrate exchange, normalization of biochemical, immunological, hematological indices in experimental animals and may be considered to be used in a combined treatment ofDiabetes mellitus.

Thesis supervisor

Khvorostov Yevgeniy Dmitriyevych

Official opponents

Міміношвілі Омарі Ісидорович
Компанієць Антоніна Михайлівна

Files

Автореферат Побеленский О.Н..doc

Побеленский О.Н. работа ВАК.doc

Similar theses

0421U101272

Vlasov Oleksandr Oleksiiovych

Effect of extract of cryopreserved piglet`s skin fragments and fullerene C60 on alterative and regenerative processes in skin after cryodestruction (experimental study)

0421U101128

Vlasov Oleksandr

Effect of extract of cryopreserved piglet`s skin fragments and fullerene C60 on alterative and regenerative processes in skin after cryodestruction (experimental study)

0420U101007

Likhitskyi Oleksii Oleksiyovych

The use of cryopreserved placental tissue for correction of the reparative osteogenesis processes of the lower jaw during an angular fracture with osteoporosis (experimental study)

0420U100468

Aidarova Victoriia Serhiivna

Effect of rhythmic hypothermia and cryopreserved cord blood on structural-functional state of central nervous system of rats with dyscirculatory encephalopathy (experimental study).

0419U003851

Chub Oleg V.

Effect of cryopreserved placental explants on course of postmenopausal dyscirculatory encephalopathy (experimental study)