Neskoromna N. Pathphysiologic mechanisms of the brain increased excitability control under the low intensity laser radiation

Features of changing epileptic activity under the influence of low intensive laser radiation of infrared diapason (LII.RID) (5 mVt, 0,89 mkm) have been determined for the first time on the patterns of focal, acute, general and chronic kindling epilepsy of the brain. Antepileptic efficiency of 1.11.RID influence in the epileptogenic formation by means of YAMK-disturbances of inhibition and stimulation of receptors, exiting amino acids and the dependence of the significance of this influence on the duration of the brain radiation have been determined. Strain oppression of a- and т- diapason in the EG spectrum under the influence of LILRID. the increase of dopamine-dependent components of conduct reactions in rats in post spasmodic period and in swimming test have been stated. The decrease of the latent period and the increase of the paradoxical sleep duration under the influence of LILRID and the dependence of this effect on the functional activity of the dopaminergetic system of the brain have been stated. The increase of the ant epileptic influence of diazepam and the influence of LILRID on the brain, disturbances in the oxidation-reduction of thiol-desulfide and ascorbate systems taking into consideration in increase of reduction forms of thiols and ascorbates have been determined. Recovery of kindling-provocative disturbances of fermentative site condition of antioxidant protection under the influence of LILRID and diazepam has been determined. Thus, the theoretical grounds and experimental investigation of the pathogenetic mechanisms of developing and the features of the acute and chronic epileptic syndrome under the influence of the laser radiation with the low intensity are given the thesis.