Сhupashko O. Functional and metabolic states of myocardium: adaptive potential and correction under experimental hypothyrosis

The thesis deals with the research of the structural and metabolic changes of blood, myocardium and liver under condition of experimental hypothyrosis. According to obtained results, the subclinical hypothyrosis is associated with increased serum levels of low-density lipoprotein and with reduced high-density lipoprotein cholesterol, and with increased atherogenic index. The measurement of the main metabolites levels of aerobic and anaerobic glycolysis was performed. The content of some products of free radical metabolism was biochemically measured. The criterias for evaluation of functional and metabolic states of myocardial tissue under experimental subclinical hypothyrosis were proposed. Morphologic myocardial markers under Intermittent hypoxic training was elaborated and tested with a purpose to correct the biochemical abnormalities.