Knysh O. Effect of cryopreservation factors on morphofunctional properties of human platelets.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0408U000555

Thesis Registration Form

0408U000555.pdf

Applicant for

Specialization

  • 14.01.35 - Кріомедицина

22-01-2008

Specialized Academic Board

Д64.242.01

Essay

The thesis covers studiying the effect of some cryopreservation factors on structural integrity and fuctional properties of human blood platelets at low temperature preservation stages. The ability of cryoprotectants of different classes of chemical compounds to scavenge the hydroxyl radicals in model system of their generation and to effect the intensity of LPO-processes in the "platelet-plasma "system was investigated. It has been shown that initial morphofunctional state of platelets, composition of cryoprotective medium and cooling rate of cell suspension within temperature crystallization interval and zone of eutectic temperatures have a crucial effect on the parameters of structural integrity and functional properties of cryopreserved platelets. For the first time it was experimentally proved that use of combination of DMAC with 1,2-PD increased the cryopreservation efficiency of platelets if compared to the application of each cryoprotectant separately.

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Files

Автореферат.doc

ДИССЕРТАЦИЯ.doc

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