Pankratiev M. Hypoxia training effect on morphofunctional adaptation of a brain cortex to myocardial necrosis

The investigation object: brain cortex adaptation to a myocardial necrosis The investigation goal: to define the possibility and mechanisms of increase in resistance and morphofunctional adaptations of brain cortex to myocardial necrosis with hypoxia training impact. Methods of research: experimental modeling of myocardial necrosis without and after hypoxia training, Electrocardiogram (ECG), intraskin oxygen pressure (РО2), catalase activity in cerebral tissue, hematoencephalic barrier (HEB) permeability, cerebrum hydration; histologic study of the myocardium; histologic, stereometric and ultrastructural study of the cerebrum were used. The theoretical and practical importance of the received results: For the first time there has been carried out complex morphofunctional research of mechanisms of adaptation of brain cortex, increase in resistance to a myocardial necrosis with hypoxia training impact. It is established, that character of changes morphofunctional parameters of brain cortex connected with development in myocardial necrosis, is one of the initial developmental process of an encephalopathy at myocardial necrosis which brings to development of a sharp hypostasis-swelling of a brain. It is established, that previous hypoxia training brings to reduction of brain swelling. In the study there have been defined quantity indicators of infringement of HEB permeability and distributions of the water content in a brain cortex after HT, as well as modelling of myocardial necrosis on intact animals and after HT. In a brain cortex there have been defined morphofunctional evidances of adaptation to HT and dysaptation at modelling myocardial necrosis with development of an encephalopathy. In the process of research it is established, that HT application may bring to transient ischemic changes in a brain which are levelled within 24 hours. The comparative analysis of morphological and functional parameters has been carried out at development of an encephalopathy without and after HT appliance. Quantitativecharacteristics of PO2 and catalase activity are given in a brain tissue at adaptation to myocardial necrosis and development of an encephalopathy. In research there has been worked out the model of dosis hypoxia and the device for its implementation. For the further experimental researches quantity indicators of infringement of HEB permeability and water contents in a brain cortex which can be used at the comparative analysis are given as well. The quantitative analysis of morphofunctional parameters of brain swelling is the basis to prognosticate changes in brain at myocardial necrosis with development of an encephalopathy. Established transient ischemic changes in a brain became the basis for restrictions of HT application to patients with ischemic illness of heart. A degree of inoculation: Results of work have been included into scientific and educational processes of faculties of pathological physiology, Lugansk, Crimean medical universities, faculties of anatomy, human physiology and animals of Lugansknational pedagogical university named Taras Shevchenko. Using sphere: medicine, pathological physiology, cardiology.