Object of the study: arrest of sexual development, disturbances in the ovarian-menstrual cycle, diffuse euthyroid hyperplasia of the thyroid gland. Purpose of the study: to reveal a relationship between an arrest of sexual development, disturbances in the ovarian-menstrual cycle at puberty and thyroid dysfunctions, to assess the efficacy of using sanatorium-resort factors in the treatment of puberty pathology in girls with diffuse euthyroid hyperplasia of the thyroid gland. Methods of the study: clinical, anthropometrical, biochemical, hormonal and instrumental examinations, statistical methods. Practical significance: on the basis of the conducted researches it was found that, irrespective of the genesis of the disease, a low concentration of estradiol and progesterone in the blood of girls with pathology of their puberty was a factor for the development of secondary thyroid pathology. A degree of the risk depended both on the absolute levels of FSH and LH, estradiol and progesterone, on the one hand,and their ratio, testosterone concentration and duration of the disease, on the other hand. It was revealed that the use of transcerebral electrophoresis of pyracetam, mud- and 5% ropa electrophoresis with sinusoid modulated currents on the area of the uterine adnexa and iodomarine drug preparation in patients with an arrest of sexual development, primary and secondary amenorhoea, polymenorrhoea and thyroid pathology at puberty was a triggering moment in the mobilization of the internal reserves of the organism, improvement of the patients’ general state. It led to the normalization of the menstrual cycle, as it was confirmed by a positive dynamics of gonadotropic hormones of the hypophysis, steroid sex hormones, as well as TTH, Т3 and Т4. Novelty of the obtained results: for the first time, a comparative characteristic of hormonal homeostasis was made in girls with an arrest of sexual development and different forms of disturbances in their menstrual cycle with an accompanying diffuse euthyroid hyperplasia of the thyroid gland; a peculiarity in the gonadotropic and thyrotropic function of the hypophysis and thyroid function in puberty pathology depending upon the level of peptide and steroid hormones of the blood. For the first time, a complex assessment of the dynamics of FSH, LH, prolactine, estradiol, progesterone, testosterone, cortisole, thyrotropic hormone, triiodothyronine and thyroxine in blood serum under the influence of sanatorium-resort treatment in girls with an arrest of sexual development, primary and secondary amenorrhoea, hypomenstrual syndrome and polymenorrhoea was made. For the first time, a differentiated com-plex of treatment was elaborated for puberty pathology depending upon the nosology, initial state of the gonadotropic function f the hypophysis, ovaries and thyroid gland in resort conditions. Degree of introduction: results of the conducted researches were introduced into medical practice of such sanatoria as Zdravnitsa (Yevpatoriya), Iskra (Yevpatoriya), named after N.K. Krupskaya (Yevpatoriya), Ukrainian Research Institute of Paediatric Resort Treatment and Physiotherapy of the Ministry of Health of Ukraine (Yevpatoriya). Theoretical propositions of the thesis were included into syllabi for students and interns of Georgievsky Crimean State Medical University. Sphere of application: medicine, obstetrics and gynaecology.
