Lutsenko B. NО-dependent mechanisms of the gastric ulcer forming at the rats during the chronic intoxication by nitrate of sodium.

The dissertation is devoted to the study of effects of excessive nitrogen oxide amount from exogenous predecessor (modelling of chronic sodium nitrate intoxication) on the structured and metabolic changes in the gastric mucous membrane as well as those depending on the functional activity of NO-syntase systems under the peptic ulcer modelling. The obtained results have shown that under the chronic sodium nitrate intoxication .О production by mitoсhondrial and microsomal electronic-transporting chains is increased, while .О production by leukocyte NADPH-oxidase is reduced; processes of lipid peroxidation become more active, ATP resyntesis is suppressed, general proteolytic activity increase as well as disorganisation of connective tissue structures in the gastric mucous membranes of Wistar white rats. Modelling of peptic ulcers on a background of chronic sodium nitrate intoxication is accompanied by intensifying of bioenergy insufficiency, increasing of superoxide anion-radical production by mitochondrial and microsomal electronic-transporting chains of gastric mucus cells, activating lipid peroxidation processes, decreasing of SOD and catalase activity; by the grows of disorganisation of connective tissue structures of gastric mucous membrane in white rats. It has been found out that the decreasing in nitric oxide production by the NO-syntase systems under the modelling of chronic sodium nitrate intoxication limits the reduction of energy production and superoxide anion-radical production by microsomal electronic transporting chain as well as by leukocyte NADPH-oxidase. Selective suppression of inducible NO-syntase results in the reduction of lipoperoxidation, while the total inhibition of NO-syntase promotes the activation of the process. It has also been revealed the reducing of nitric oxide production by inducible NOS limits the disorganisation in connective tissue structures of gastric mucus in white rats.