Trushenko O. Coordination of the periodic activity of the gastroduodenal zone in its function-and-morphological integrity disturbance

The motor-and-secretor activity of the stomach and duodenum in disturbances of the functional-and-morphological integrity of gastroduodenal zone was researched in dogs and rats. It was found out that vegetative system disbalance had caused changes of acid secretion in the fasted state, increase of gastric secretor response to exogenous histamine and a case of "regulatory rejection". In rats duodenogastric reflux caused disturbances of the phasic nature of the gastroduodenal myoelectrical activity, which was associated with the spike-activity predominance and the tendency of the duodenal rhythms to diffuse on the stomach. It was associated with the decrease of the aggressive properties of gastric juice and the increase of its volume. It was found out that the NO-ergic regulation had preserved its inhibitory influence on the contractile activity of the antrum and duodenal bulb, and the decrease of the gastric juice volume could be fixed in NO-syntase-blocked state with nearly unchanged pepsin and glycoprotein concentrations, and pH level.