Sadlyak O. Lymphocyte mediated mechanisms –in conditions of chronic hyperimmunocomplexemia and Korvitin influence upon them, in the experiment

The dissertation work is devoted to study of peculiarities of flow of NO-syntase and arginase ways of L-arginin system metabolism – in lymphocytes and in endotheliocytes, in conditions of chronic experimental hyperimmunocomplexemia, and in case of search problem of this pathology correction. It was estimated, that the development of chronic hyperimmunocomplex in animals, which caused immunological, biochemical and morphological changes in lymphocytes and in endothelial cells, – is stipulated by considerable violation of processes of nitric oxide synthesis. The changes in nitric oxide metabolism in these conditions – are manifested by growth of NO dependent inducible processes, oppression of its constitutive NO syntase activity, and the development of nitrose-active stress in cells. The received data testify to arginase synthesis activation, in hyperimmunocomplex pathology conditions. The Corvitin application is manifested by intensive corregating action in nitric oxide system, and by functional activity of lymphocytes and endotheliocytes in animals with chronic hyperimmunocomplexemia, in vitro and in vivo conditions. The normalising effect of Korvitin is manifested also by improvement of the ultrastructure of the investigated cells.