Vlasenko Y. Synthesis, chemical properties and biological activity of 3,5-dіаmіnо-thiophenes with electron-withdrawing substitutes in positions 2 and 4

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0408U003044

Thesis Registration Form

0408U003044.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

30-05-2008

Specialized Academic Board

Д64.605.01

Essay

For the first time a „one-pot" technology of synthesis of substituted 3,5-diaminothiophenes has been developed through interaction substituted acetonitriles, arylisothiocyanates and substituted phenacylhalogenides. For the first time salts of N,S-acetalketenes and DBU have been obtained and studied. A possibility of bringing of different substitutes in positions 2 and 4 have been studied. Properties of 3,5-diaminothiophenes in reaction of acylation have been studied. For the first time 2-nitro-3,5-diaminothiophenes from inters 3,5-diamino-thiophenes and nitrosating reagents have been synthesized and the probable mechanism of carrying reaction have been proposed. 280 unentered compounds have been synthesized. For the first time a virtual screening of combinatorial library of substituted 3,5-diamino-thiophenes has been carried out using program PASS. A pharmacologic screening has been carried out and analgesic, antimicrobial, hypolipidemic and anti-inflammatory activities of 3,5-diamino-thiophene derivatives have been studied.

Read more

Files

Dissertacia--3MICT.doc

Dissertacia--ВСТУП.doc

Dissertacia--Додаток A.doc

Dissertacia--Додаток Б.doc

Dissertacia--Додаток В.doc

Dissertacia--Додаток Г.doc

Dissertacia--Додаток Д.doc

Dissertacia--Додаток Е.pdf

Dissertacia--ЗАГАЛЬНІ ВИСНОВКИ(готовий).doc

Dissertacia--Раздел 1(готовий).doc

Dissertacia--Раздел 2(готовий).doc

Dissertacia--Раздел 3(готовий).doc

Dissertacia--Раздел 3(готовий).doc

Dissertacia--Раздел 4(готовий).doc

Dissertacia--Раздел 5(готовий).doc

Dissertacia--СПИСОК ВИКОРИСТАНИХ ДЖЕРЕЛ.doc

Dissertacia--Тітул.doc

Автореферат.doc

Similar theses

0523U100273

Lozynskyi Andrii V.

Polyfunctional condensed and non-condensed thiazole/thiazolidinone derivatives: directed synthesis, physicochemical properties and biological activity

0523U100081

Safonov Andrii A.

Синтез, перетворення, фізико-хімічні і біологічні властивості похідних 1,2,4-триазолу, які містять тіофен-2-ілметильний замісник

0523U100030

Bihdan Oleksii A.

Synthesis, chemical modification and biological properties of 3-, 4, 5-trisubstituted-1,2,4-triazole-3-thions

0521U101625

Borodina Nataliia Valerivna

Pharmacognostic study of willow plants and creation of medicines based on them. Qualifying scientific work on the rights of the manuscript

0421U102935

Anosova Liydmila Sergееvna

Chemical and toxicological study of clopidogrel