Kless O. Functional and metabolic distinctions in cardiovascular system influenced by the various levels of ionizing radiation (experimental research)

The dissertation adresses the mechanism of influence that the fractional irradiation in low (1 Gy) and high (10 Gy) doses produces in the heart rate variability, as well as in the periferal blood values and the free-radical homeostasis.The effect of intermittent hypoxic training prior to the influence of low dose of radiation has been investigated.Irradiadion in the dose of 1 Gy caused development of inssuficient adaptation, decrease in the tone of parasympathetic and increase in activity of the sympathetic nervous system which indicates distress.The influence of the high dose of ionizing radiation manifests as a more expressed inhibition in activity of antioxidative enzymes evaluated in experiment, also as an increse in sympathetic tone and more noticeable decrease in parasympathetic tone after the first fraction of radiation.The positive effect of intermittent hypoxic training prior to the influence of low dose of radiation expressed itself via an improvement in efficiency of functional and metabolicprocesses during the post-exposure period.