Tykhokhid L. Modelling and ways of experimental correction of deficiency of iron to an organism of rats

The investigation object: iron deficiency conditions.The investigation goal: determination of basic patogenetical mechanisms of the initial stages of experimental hyposiderosis (latent deficiency of iron) and participating in them of liver and intestine with a subsequent correction with the use of ferrous mineral waters in a complex with saponite clays. Methods of research: pathophysiological (modelling of deficiency of iron), hematological, biochemical, morphological, histochemical, physiological and statistical.The theoretical and practical importance of the received results: the received results of research are extend picture of pathogenesis of latent deficit of iron and role of liver and mucous membrane of intestine in development of this pathology. The model of latent deficiency of iron is developed for rats with the use of original diet with change of qualitative and quantitative salt mixture (patent on an invention). The received model can be used in researches of new methods of its correction.The received results can be theoretical basis for development of recommendations on applied of mineral water «Nastusya» and saponite clays at the latent deficit of iron.The scientific novelty of the investigation results: it is first certain that as a result of finding of rats on a original diet is arises hyposiderosis (latent deficit of iron). It, in same queue, through affecting the state of epithelium of thin intestine and function of liver, results in violation of suction in an intestine, to the decline of activity of the fiber-synthesizing function of liver. Terms are created for proof and long violation of exchange of iron. The changes of hematological, biochemical, morphological and histological indexes are first studied for healthy rats, and also for rats with the latent deficit of iron at the protracted introduction of ferrous mineral water «Nastusya» separately and in combination with saponite clays. It was shown, that feeding of iron in a gastroenteric part in the well-assimilated form not completely restores the exchange of iron, if processes of suction and depositing of iron are broken. Expedience and efficiency of the course combined applied ferrous mineral water «Nastusya» with saponite clays at the latent deficit of iron. The combination of surplus of iron with the complex of microelements results in renewal of liver and intestine functions and proved causes renewal of exchange of iron.The degree of implementation: the results of the research are inculcated in an educational process on the department of general and clinical pathophysiology of the Odessa State Medical University, on the department of physiology of man and animals of the Odessa National University named by I.I. Mechnikov. It is drawn on the results of theoretical researches as basis for forming of more adequate courses of treatment of anemia in a policlinic № 5, in a city clinical hospital № 11, in a clinical sanatorium named by V.P. Chkalov, in a clinical sanatorium «Lermontovskij» (Odessa). Branch of usage: medicine, biology, pathological physiology.