Onyshchenko O. Remodeling and dynamics of heart left chambers systolic function and clinical-functional conditions of patients with cardiomegaly and congestive heart failure of different genesis under the long-term syndromes' pharmacotherapy

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U002238

Thesis Registration Form

0409U002238.pdf

Applicant for

Specialization

  • 14.01.11 - Кардіологія

28-04-2009

Specialized Academic Board

Д 26.616.01

State Institution National Scientific Center "The M.D. Strazhesko Institute of Cardiology National Academy of Medical Sciences of Ukraine"

Essay

The dissertation is devoted to systolic congestive heart failure (CHF) improvement under the contrastive examination of clinical-functional and ultrasound indices of patients with cardiomegaly and CHF of different genesis as affected long-term syndrome treatment with the use of carvedilol high therapeutic doses. It was proved, that due to slow titration (on the average 12,08±0,99 months) the high therapeutic dose of carvedilol (100 mg/daily) are succeeded to attain in 76,7% and optimal dose of enalapril (20 mg/daily) - in 75,8% patients with cardiomegaly and CHF of different genesis accordingly. It is exposed, that such therapy during long while is well carried by patients, does not cause serious side effects, does not worsen a five-year prognosis, results in proof improvement of patients' functional class and lowering of furosemide week's dose regardless of syndrome aetiology. However only in patients with clinical diagnosis "chronic diffuse myocarditis" offered treatment conduced left heart chambers'reverse remodeling and lead to normalization of meaning of LV iEDV in 30%, LVEF - in 52,4%, LA ESV index - in 45% of such patients. Patients in which normalization of LV cavity is succeeded to attain are characterized by less duration of CHF symptoms (5,54±1,48 months) and more high initial level of systolic blood pressure (125,00±5,40 mmHg).

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Files

АКТИ ВПРОВАДЖЕННЯ.doc

АвторефератОнищенко О.В..doc

Дисертація ОНИЩЕНКО О.В--АКАДЕМІЯ МЕДИЧНИХ НАУК УКРАЇНИ.doc

Дисертація ОНИЩЕНКО О.В--ВИСНОВКИ-41.doc

Дисертація ОНИЩЕНКО О.В--ВСТУП-4.doc

Дисертація ОНИЩЕНКО О.В--Додаток 4.doc

Дисертація ОНИЩЕНКО О.В--КОР-НЕКОР-УКР4.doc

Дисертація ОНИЩЕНКО О.В--КОР-НЕКОР-УКР41.doc

Дисертація ОНИЩЕНКО О.В--Материалы и методы-4.doc

Дисертація ОНИЩЕНКО О.В--ОБГОВОРЕННЯ-4.doc

Дисертація ОНИЩЕНКО О.В--ОБЗОР ЛІТЕРАТУРИ-4.doc

Дисертація ОНИЩЕНКО О.В--Переносність лікування-4.doc

Дисертація ОНИЩЕНКО О.В--СПИСОК ЛИТЕРАТУРЫ-4а.doc

Дисертація ОНИЩЕНКО О.В--ХМ-ДКМП-4.doc

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