Olkhovyk V. Pathogenetic substantiation of diagnostics and treatment of pregnant women suffering from diffuse euthyroid hyperplasia.

The subject of the research is diffuse euthyroid hyperplasia. The object of the paper is to define pathogenesis peculiarities of pregnancy complications of women suffering from diffuse euthyroid hyperplasia considering hormonal status indices, metabolic processes and hemostatic system and to develop science-based approaches to early detection and timely correction of the identified abnormalities. The methods of the research are the following: clinical-laboratory, biochemical, hormonal, ultrasound, hemostatic and statistical methods. Theoretical and practical results. The defined changes of hormonal status, metabolic processes and hemostatic system are important for the specification of gestation pathogenesis peculiarities and for providing differential approach to the complex of treatment and preventive measures for the pregnant suffering from diffuse euthyroid hyperplasia. The diagnostic importance of those indices for controlling the treatment efficiency has been ascertained. New pathogenetically valid medicine “Barba-iodine” has been suggested for iodine balance renewal, which also improves metabolic processes, activates antioxidant system, improves adaptive and immune possibilities of the organism, decreases toxins and medicaments influence, improves blood quality and prevents asiderotic anemia. The novelty. It is for the first time that the functional state of the system mother-placenta-fetus among women suffering from diffuse euthyroid hyperplasia has been studied, the role of transitory gestational thyrotoxicosis in the I trimester and subclinical hypothyroidism for pregnancy complications has been proved. Connection between thyroid status changes, metabolic processes and hemostatic indices of the pregnant with diffuse euthyroid hyperplasia has been specified. For the first time gestational period peculiarities, confinement results and state of newborn children of the women with euthyroid hyperplasia have been studied. For the first time the fact that women with diffuse euthyroid hyperplasia have the growth of lipid peroxidation intensity, decrease of antioxidant protection system activity, change of hemostasis indices has been stated. For the first time science-based complex of treatment and preventive measures has been developed and provided to decrease the frequency of obstetrical and perinatal complications for the pregnant with diffuse euthyroid hyperplasia; the method is based on differential approach to conducting this group of patients. Sphere of application: medicine, obstetrics and gynaecology