Research object: excessively strong and discoordination laborl activity. The purpose of research: To lower frequency and risk of development excessively strong and discoordination laborl activity by study of questions of their pathogenesis and correction of calcium antagonists with a preliminary clinical -experimental ground of such therapy. Research methods: clinical-laboratory, immunological, hormonal, instrumental, experimental and statistical methods. Theoretical and practical results: On the basis of data analysis and methods of regulation of contractive activity of uterus are improved at excessively strong and discoordination laborl activity by pathway inclusion in the complex of adjunctive therapy of calcium antagonists. The factors of risk of development are certain excessively strong and discoordination laborl activity. Devise by schemes for predelivery preparation of pregnant with the risk of development of excessively strong and discoordination laborl activity with the use of antagonists of calcium. Install of sequence, doses and speed of introduction of preparations of this group, with the particularity of delivery, that will allow to reduce the amount of complications in labor, to decrease the indexes of perinatal morbidity and mortality. Novelty: The complex analysis of pathogenetic mechanisms of development is first conducted excessively strong and dis-coordination laborl activity with the study of calcium exchange, parameters of hemostasis, haemodynamic disturbance, immunological and cytokine profile, hormonal and clinico-biochemical parameters. The show unfavourable influence is excessively strong and discoordination laborl activity on the flow of delivery ,condition of mother and fetus. For the first time on experimental models in vivo and in vitro is studied the action of antagonists calcium is on contractive activity of myometrium. The proved of prescription of calcium antagonists by in optimum-effective dose regimes regulates setting of antagonists of calcium contractive activity of uterus, instrumental in the correction of hemodynamics, system of hemostasis, immunological status and hormonal disturbance, at this connection with tham expedient to apply in labour at development of these pathological condition. Are developed the new approaches and schemes of predelivery preparation of pregnant of risk group is development excessively strong and discoordination laborl activity, taking into account their general, clinical, hormonal and cytokine profile. This indicates that application of antagonists of calcium at excessively strong and discoordination laborl activity is had advantage as compared to the traditional methods of therapy and promote in the reduction of number complications in labour, to decrease the indexes of perinatal morbidity and mortality. Degree of introduction: The developed methods of treatment are inculcated in pactical work of delivery houses № 1, 5 in Kharkov, Ukrainian theoretical and practical medical center of obstetrics, gynaecology and reproduction Kharkov National Medical University (KNMU) , Regional clinical hospital, maternity hospital of the Sonth railway Kharkov. Theoretical positions and practical recommendations of dissertation work are utillized in the pedagogical process of department of obstetrics and gynaecology №1 KNMU, departments of obstetrics and gynaecology №1 to the Kharkov Academy of postgraduate education. Sphere of the use: medicine, obstetrics and gynaecology.
