Podolsky I. Synthesis, physico-chemical and biological properties of alkylderivatives of 2-methyl-1H-quinolin-4-ones

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U003234

Thesis Registration Form

0409U003234.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

19-06-2009

Specialized Academic Board

Д64.605.01

Essay

Preparative methods of synthesis of O- and N-alkylderivatives of 2-methylquinolones, 3-N-R-aminomethyl-2-methylquinolin-4-ones, 2-N-R-aminomethyl-3-benzyl-quinolin-4-ones, 3-alkyl-2-methylquinolin-4-ones and their 4-chloro-, 4-thio- and 4-aminoderivatives have been elaborated. Investigation of nootropic, antidepressive and anxiolytic activity of 3-aminomethylderivatives of 2-methylquinolin-4-ones has been carried out. It has been shown that nootropic (antiamnestic) activity is inherent for this class of compounds. In addition, some of examined derivatives combine nootropic and antidepressive or anxiolytic activity. Moreover, certain regularities of structure - biological activity relationships have been revealed. The influence of (2,8-dimethylquinolin-4yl)oxyacetamides on thiopental narcosis duration has been studied. Antimicrobial properties of 3-alkyl-2-methylquinolin4-ones and their 4-chloro-, 4-thio- and 4-aminoderivatives has been investigated.

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Files

Автореферат--Автореферат.doc

Диссертация--1 - Титульний аркуш.doc

Диссертация--10 - Список літератури.doc

Диссертация--11 - Додаток А.doc

Диссертация--2 - Зміст.doc

Диссертация--3 - Вступ.doc

Диссертация--4 - Огляд літератури.doc

Диссертация--5 - Розділ 2.doc

Диссертация--6 - Розділ 3.doc

Диссертация--7 - Розділ 4.doc

Диссертация--8 - Розділ 5.doc

Диссертация--9 - Загальні висновки.doc

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