Korobova A. Рeculiarities of hypertensive discirculation encephalopathy depending on adrenoreactivity of the organism

The dissertation is dedicated to complex study of clinic, diagnostic and treatment approach to the issue of hypertensive discirculation encephalopathy depending on different adrenoreactivity in patients. It was determined that dizziness, more intensive and frequent headache of tension, inaccuracy in finger-to-nose test and dysdiadochokynesia, more pronounced signs of autonomic disfunction with paroxysmal course predominate in patients with the Ist stage hypertensive discirculation encephalopathy and high etaadrenoreactivity. Hypertensive discirculation encephalopathy in patients with higher betaadrenoreactivity is characterized by more pronounced rise of diurnal and daily systolic arterial blood pressure, insufficient decrease of night arterial blood pressure, increase of diurnal variability, increase and prolongation of morning rise of arterial blood pressure; decrease of circulation in vertebral-basilar system according to ultrasound dopplerography. After treatment with beta-blocker nebivolol intensity and frequency of dizziness decreased, depression and anxiety evidence reliably decreased, frequency and intensity of autonomic dysfunction decreased in patients with high betaadrenoreactivity level, as long as in patients with low betaadrenoreactivity level these changes were not so evident. Arterial blood pressure and its variability and degree, prolongation of morning rise of arterial blood pressure reliably decreased, and the blood flow reliably increased in patients with high betaadrenoreactivity, as long as in patients with low betaadrenoreactivity these changes were inessential. Use of beta-blocker nebivolol is indicated in high betaadrenoreactivity for correction of discirculation encephalopathy in patients with arterial hypertension. The method of detection of target group of patients with hypertensive discirculation encephalopathy is proposed for effective beta-blockers prescription. Key words: arterial hypertension, discirculation encephalopathy, adrenoreactivity, beta-blockers.