Latyshenko L. The mechanisms influences of enkephalins on bile secretion in liver (experimental research)

Object: regulation of bile secretion function of liver. Aim: to study the mechanisms of influence of met-enkephalin, ley-enkephalin and dalargin of blocading opioid receptors, receptors of autonomous nervous systems and activity acetilcholinesterases. Methods: physiological, biochemical, statistic analysis. Results: The studies about the choleresis level and chemical compositions of bile under the effect of these peptides were conducted in acute experiments in common bile duct cunnulated rats. Blocading of opioid receptors by naloxon showed less cholerethic effect of enkephalins. The blocading of adrenoreceptors showed opposite enkephalin on choleresis. Blocaded H-cholinoreceptors canceled stimulating effects of ley-enkephalin and dalargin on contents conjugated bile acids. Opioid peptide increase the catabolism of catecholamins. Novelty: for the first time the of blocading of opioid receptors and receptors of the autonomous nervous system the influence of met-enkephalin, ley-enkephalin and dalargin was studied. We've shown the dependence of the hypocholeretic met-enkephalin effect from alfa- and beta- adrenoreceptors. The effects of ley-enktphalin and dalargin on bile secretions depend upon the activity of alfa- adrenoreceptors and holinoreceptors. We've that opioid peptide increases catabolism of catecholamins of urine. It is introduced in the educational process of the biological department Taras Shevchenko Kyiv National University, Kyiv. Field of the use: physiology, medicine.