Skybiuk A. Comparative research of dissolution of non-steroidal anti-inflammatory solid dosage drugs forms

We have described approaches to find the best conditions for dissolution test and dissolution profiles for solid dosage drugs containing paracetamol, nimesulide, celecoxib for quality control of drugs and detection of falsifications. We have also determined the best dissolution environment for quality control of paracetamol-containing tablets. Researching the dissolution profiles, we have also studied the method of spectrophotometric determination of celecoxib and established its validation characteristics. Also, we described best compositions of dissolution mediums needed to receive informative profiles of release of celecoxib and nimesulide from solid dosage drugs forms and influence of various factors on the celecoxib release. Studies of kinetics of paracetamol release from combined drugs with diclofenac allowed us to offer the optimal conditions to obtain dissolution profiles and explain the need to examine them at the quality control stage prior to the drug registration and detected of falsifications.