Savchuk R. The role of energy changes of detrusor tissue in pathogenesis of hyperactive urinary bladder development (an experimental research).

The thesis is devoted to the experimental substantiation of principle strategy in treatment of hyperactive urinary bladder (HUB) on the basis of study of dynamics of structural-bioenergy and functional changes of detrusor under the influence of new chemical compounds which have a combined energotropic and anticholinergic activity. With the help of research on the isolated urinary bladder it is established the minimum effective concentrations of the investigated compounds (nicotinoylhydra-zon paradimethylaminobenzaldehyde (Hndb), the complex of germanium (IV) with Hndb, the complex of germanium (IV) with nicotinamide, quercetin, and trospium chloride), which were used during 21 days in animals with an experimental hyper-reflectory urinary bladder. There are examined pathophysiological changes in detru-sor of the HUB animals which are based on metabolic disorganization, damaging in-fluence of free radical lipid oxidation products on the detruzor cells' membranes, and decline in levels of anti-oxidant defence enzymes, Ca2+ of ATPh, activation of energy profile, which takes place with energy reserve overspend. At comparing of coordina-tion compounds with germanium, the complex of germanium (IV) has the best activ-ity with nicotinamide. Its mechanism of action is based on ability to diminish the de-gree of oxidation processes, stabilize the energy profile and metabolism of cells due to high cytoprotective activity, which confirms expediency of their subsequent study and further introduction into the clinical practice. It is proven the efficiency in treatment of experimental hyperactive urinary blad-der with the combination of m-cholinoblockers and energy tropic agents on the ex-ample of trospium chloride and quercetin. They stabilize the indices of energy me-tabolism in the detruzor cells, that testifies to stabilization of cytoenergy potential of a cell.