Yemelyanenko V. Role of leu-enkefalins in the regulation of gastric secretion, processes of cytoprotection, and blood flow under conditions of activation or blockage of different groups of receptors in gastric mucosa

Object - mechanisms of gastric glands secretion, metabolic and cytoprotective processes in mucous coat of stomach. Purpose - to determine participation of leu-enkephaline (dalargin) in regulation of gastric secretion, blood flow and processes of cytoprotection in mucous coat of stomach under conditions of activation and blockage of cholinergic receptors, D2-receptors and change of NO-synthase system activity. Methods - perfusion, titrimetric, colorimetric, spectrophotometric, method of hydrogen clearance, planimetric, histological, statistical. Results - peculiarities of effect of opioid peptide dalargin on secretory function of gastric glands, blood flow in mucous coat of stomach and processes of gastroprotection under conditions of blockage or activation of NO- synthase system different activity. Novelty - role of opioid peptide dalargin in case of its independent and combined effect with agonists and blockers of different receptors of mucous coat of stomach on secretory function of gastric glands, blood flow, processes of cytoprotection and lipoperoxidation have been studied. It was noted that dalargin can modulate course of physiological processes that will depend on functional state of receptor apparatus of mucous coat of stomach and system of L-arginine – NO-synthase. Introduction - results of investigation were adopted into educational process of department of human and animal physiology of Taras Shevchenko Kyiv national university, departments of normal physiology of Danila Galitskiy Lviv national medical university, Dnepropetrovsk state medical academy. Branch - medicine (physiology).