Duzhak G. Changes of the blood rheologicsl properties and microvessels endotelial function in aging

Object: Blood rheology and functional state of the endothelium micro vascular bed in essentially healthy people in the age range 20 to 89 years. Purpose: Elucidation of blood rheology properties and the endothelium functional state at the level of microcirculatory vascular bed in essentially healthy people with aging and, second, the development of approaches to correction of detected disorders. Methods: Commonly used (instrumental and laboratory) methods for selecting healthy subjects of different ages and special methods used for assessing rheologic blood properties such as blood viscosity, venous blood hematocrit, erythrocyte charge, erythrocyte deformity, platelet and erythrocyte aggregation, endothelium functional state and its vessel motoric function. This work has first demonstrated changes in the blood rheologic properties in the essentially healthy people during aging. Such changes showed themselves in the increase of blood viscosity, in the worsening of functional state of cellular and plasma factors. The author's data have been first to reveal disorders in the vessel-motoric function of the endothelium of the microcirculatory vascular bed as a function of age. Age-dependent changes of the endothelium functioning were found to develop at already 40-49 years and increase with age. It has been first that correlations were found between the state of endothelial function of the microvascular bed and rheologic properties of the blood. The data have been obtained first showing that in elderly people there takes place improvement of the endothelial function of the microvascular bed following both, single administered and especially course treatment with the drug Korargin, containing L-arginin and riboxin. The author's study was first to investigate the compensatory possibilities of the blood rheologic properties and endothelial function of the microvascular bed in the healthy people of different age while applying loadings like hypoxia, stress and fat food intake. Decrease of aging individual's resistance to these stresses has been established thus worsening our researchers' vision about a role played by age-associated changes of the blood rheologic properties and of the endothelial function of the microvascular bed in the development of some kinds of pathogenesis. The author has been first to study the pharmacodynamics (anti-aggregation effect) of the acetyl salicylic acid (ASA), being administered in the various doses to healthy people. As a result the optimal dose of ASA, 125 mg once a day has been fixed. The results have been introduced into scientific process at the Department of Therapy and Geriatrics in the P.L. Shupik National Medical Academy for Postgraduate Education of Health Ministry of Ukraine, and at the Department of General Medicine and Cardiology in the D.F. Chebotarev State Institute of Gerontology of National Academy of Medical Sciences of Ukraine. The field is medicine.