Cherevko O. The role of autoimmune inflammation, heat shock proteins, cytokines share in course of acute myocardial infarction.

The dissertation is devoted to determination of relationship remodeling of atrium and ventriculum, proinflammatory, including autoimmune and inflammatory factors in patients with acute myocardial infarction (AMI), establishing criteria for diagnosis of disease characteristics as a prerequisite for correct treatment. The diagnostic criteria of inflammatory syndrome with autoimmune component as risk factors for complicated course of acute myocardial infarction based on a combination of clinical manifestations of ischemia, bionecrosis, myocardial necrosis, pulmonary edema, cardiogenic shock, vitally dangerous cardiac rhythm and conductivity, the formation of acute left ventricular aneurysm, increasing the quotient of autoantibodies to the heat shock proteins 60 to the level of IL-10 more than 4.99 arbitrary units, quotient of autoantibodies to the heat shock proteins 60 to the level of CRP more than 4.2 arbitrary units, reducing the quotient of CRP to IL-10 less than 0.2 arbitrary units. It was established the role of left ventricular, biventricular types of the heart remodeling in AMI course. It was proved the relationship between biventricular type of the heart remodeling and risk of the alveolar pulmonary edema, cardiogenic shock in patients with AMI. It was established the risk factors for aggravation of inflammatory reactions, including proautoimmune protect of the cardiovascular system - reducing anti-inflammatory interleukin-10, increasing the quotient of the level of autoantibodies to the heat shock proteins 60 to the level of IL-10 in patients with AMI: availability of postinfarction cardiosclerosis, Dresler syndrome. It was clarified the diagnostic criteria of role of angina pectoris, which is previous to acute myocardial infarction as a protective determination factor to ischemia-reperfusion, complicated course, the intensity of aseptic inflammation, anti-inflammatory action of interleukin-10.