Lenkov A. Peculiarities of brain structures ischemia-reperfusion injury course against a backgraund of diabetes mellitus in male rates.

Object - ischemia-reperfusion injury of a brain on a background experimental diabetes mellitus; the purpose - will define features of reaction different structures of a brain on an incomplete global ischemia and the subsequent reperfusion at male rates with an experimental diabetes on separate genomic, biochemical and morphological to parameters; methods - immunofluorescent, biochemical, morphological, mathematical; results - it is established, what on expression proteins р 53, Hif - 1, That Bcl-2 reaction of genome on bilaterial an ischemia-reperfusion injury of a brain as control male rates and animals with a diabetes has the structural features; it is shown, what during the period of ischemia-reperfusion damages of a brain to a bark of a frontal share of animal both groups grows expression genes р 53, Hif - 1, That Bcl-2, it is more essential at animals with a diabetes, and there are no changes expression proteins р 53; The maintenance of products of lipid peroxidatoin is established, that in examine structures of a brain of rats with a diabetes, as a whole, oxidizing updating of proteins and activity of enzyme is lower than at male rates without infringements than a carbohydrate exchange, at rats with a diabetes intensity lipid peroxidatoin and proteins remains almost constant, and the antioxidative potential - is reduced; it is shown, that the diabetes reduces proteolytic activity in a bark of a frontal share and field СА1 of hypocampus, and strengthens here in - fields СА2 that СА3 and raises fibrinolitic activity practically in all structures, and reaction proteo-and fibrinolitic activity on an ischemia - reperfusion at a diabetes is reduced in comparison with animals without infringements of endocrine functions of a pancreas; it is revealed, that the ischemia - reperfusion at a diabetes promotes more powerful pathomorphological to changes in researched departments of a brain, than at control animals.