Kartick P. Autoimmunization processes in pre-eclampsia and eclampsia and their clinical implications.

This work is dedicated to the study of processes of autoimmunization in pregnant women with pre-eclampsia and eclampsia and their clinical significance. The conducted investigations of 120 pregnant women with this given pathology showed that a level of neurospecific enolase of 5 ng /ml in the blood serum of these patients may be perceived as a diagnostic criterion for the development of preeclampsia. We have found that the level of neurospecific enolase increases several times, depending on the severity of preeclampsia. The content of pro-inflammatory interleukins (interleukins-1, interleukins-2, tumor necrosis factor) in the blood of pregnant women with pre-eclampsia was significantly increased, and anti-inflammatory (interleukins-10) decreased depending on the severity of pre-eclampsia. We have also noted increasing T-helpers (CD4) and natural killer (CD16), and reduced levels of T-suppressors (CD8) in pregnant women with pre-eclampsia. Doppler velocimetry of peripheral vascular resistance in the uterine artery, spiral arteries and the umbilical artery were significantly increased in pregnant women with symptoms of pre-eclampsia when compared to women with physiological pregnancy, and in the middle cerebral artery decreased in pregnant women with mild pre-eclampsia, but then significantly increased in women with increasing severity of pre-eclampsia. We have found a strong correlation between changes in these indicators and the level of neurospecific enolase in the blood of those women, which can be considered as a new theory in the pathogenesis of pre-eclampsia.