Shatova O. Peculiarities of carbohydrates and nucleotides metabolism under breast tumor

Object of investigation is state of carbohydrate and nucleotide metabolism in tissues and blood cells of patients with fibroadenoma and breast tumor; methods - pathophysiological, biochemical, immunohistochemical, statistical; newness and results - it's determined that the carbohydrates and nucleotides metabolism changes are related to the character of the proliferation abnormalities: in fibroadenoma (FA) tissues the rate of glycolysis is increased, and penthoso-phosphate pathway (PPP) of glucose oxidation and purine and pyrimidine nucleotides catabolism slow down; in adenocarcinoma (AC) tissues increased rates are observed not only for glycolysis but also for PFP, and catabolism of purine, but only catabolism of pyrimidine nucleotides is decreased; it is showed that upon proliferation of malignant cells the carbohydrates and nucleotides metabolism changes have systemic character; it is revealed that at the later stages of breast cancer LDH, G6PDH, ADA activities in tumor tissue are increased, in contrast to TP activity that goes down; it is found in first time that the degree of histological differentiation of breast AC doesn't depend on the state of carbohydrates metabolism, and low differentiated carcinoma are characterized less activity of adenosine catabolism; it is showed that for patients with progesteron-positive AC the activity of serum TP is higher, than for patients with progesteron-negative tumors; it is first found out that upon proliferation of both fibro adenoma and breast tumor cells the direct connection between the glycolysis and catabolism of purine nucleotides rates exists; it is found that ADA in tumor tissue is more sensible to inhibitory impact of acidosis; it is first exhibited that the lactate ions increase activity of key enzyme of adenosine catabolism and stimulate migratory ability of leucocytes by of dose-dependent way; introduced - in educational process at departments of pathophysiology of Donetsk National, Zaporozhia, Lugansk, Crimean, Ternopol'skogo state medical universities in the lecture course "Pathophysiology" and also in the research work; sphere of usage - is an educational and scientific processes on the departments of pathophysiology, oncology.