Zakharenko N. Prophylaxis of obstetrics complications in women with pathologic preliminary period.

In this work is presented data that shows, that most of deliveries that had pathologic preliminary period in the beginning had afterwards different obstetric and perinatal pathologies. It indicates that pathologic preliminary period more often occurs in women with neuroendocrine pathology against the background of obstetrics and gynecologic anamnestic record. Analysis of laboratory and functional data was held in time dynamics, starting from the moment of cramp-like pain. It is established, that pathologic preliminary period develops in women with immature and not fully mature uterine neck in combination with anomalous uterus contraction function. During analysis of fetus in pathologic preliminary period condition was established manifestation of distress, related to dysfunction of fetoplacental complex, that is conditioned by hemodynamic shift in mother-placenta-fetus system and decrease of estriol and placental lactogen. Have proved the fact of endocrine dysfunction role, that lays in high Progesterone/Estradiol correlation, high level of human choriogonadotropin and cortisole, cytokine system disbalance and NO in blood and cervical content, as well as participation of cholinergic structure mostly with vegetative nervous system parasympathetic link predomination in development of pathologic preliminary period. Pathologic preliminary period prognosis criteria were developed according to received data and worked out pathogenetic based complex of medical correction towards establishment of balance between not the right time uterus activity in case of unmature to delivery uterus neck with the use of NO donator and cholinolytic substance. Proved the reasonability of early treatment start. It's effectiveness lays in achievement of more mature uterus neck, normalization of labor activity, fetus state, decrease if obstetrics complications.