Lavro Z. Peculiarities of changes of the functional state of endothelium and heamostasis in the dynamics of development of ulcerous illness of stomach and duodenum.

An object is ulcerous illness of stomach and duodenum, neouslozhnenaya and complicated bleeding; purpose - to expose the features of intercommunication between violations in the system to gemostazu and functional consisting of endothelia of dynamics of ulcerous illness of stomach and duodenum for the patients of different age-dependent groups and to set their prognosticheskoe value in relation to the origin of bleeding;iaoiae haematological - for a count amounts of thrombocytes are in blood; koagulogicheskiy -dlya determinations are in blood of protrombinovogo time, activated parcial'nogo tromboplastinovogo time, to content of Fibrinogenum and soluble fibrin-monomernikh complexes, trombinovogo time, activity of antithrombin, and systems of protein With, to time of euglobulinovogo lysis; imunofermentniy - for determination of content of factor of growth of endothelia of vessels and basic factor of growth of fibroblastov in blood; mathematical - for the statistical working of digital data; results - in the first time the complex study of changes of indexes of the system is conducted to gemostazu and rostovykh factors of vascular wall at ulcerous illness depending on age of patients and at complication of motion of disease bleeding; z''yasovano, that the uncontrolled strengthening of coagulation is a substantial nosotropic factor relapses of ulcerous illness of stomach and duodenum; thus intensification of hypercoagulability on a background violation of functioning of protizsidal'noy and fibrinolytic systems instrumental in deepening of hypoxia of vascular wall, eliminacii of rostovykh factors which are one of mechanisms of progress of ulcerous illness, in particular, origin of bleeding; in the first time basic indexes are studied to gemostazu at ulcerous illness of stomach and duodenum depending on age of patients; for the patients of mature age ulcerous illness is accompanied hypercoagulative changes with the simultaneous increase of potential activity to plazminogenu, to the declines of activity to the antithrombin ??? and by an origin in part of patients of chronic syndrome of diseminovanogo of the vnutrisosudistogo displacing of blood with the protracted maintainance hypercoagulabilitys; it is set that for patients preklonnykh years the increase of general coagulative potential of blood is accompanied decompensation of mechanisms of adaptation, namely: diminishing of potential activity to plazminogenu, antitrombinovoy activity of blood, exhaustions of fibrinolysis and increases of percent of patients, with the signs of chronic syndrome of diseminovanogo of inopexi; aggravating gemokoagulyaciynikh disorders results in progress of ulcerous illness; it is rotined that origin of the gastroenteric bleeding for patients accompanied ulcerous illness by development of sharp syndrome of diseminovanogo of the vnutrisosudistogo displacing of blood with the signs of coagulopathy of consumption and diminishing of functional ability of thrombocytes.