Lapovetc N. Pathogenesis of immune and cytokine disregulation in acute appendicitis and abdominal tuberculosis

Object - is abdominal tuberculosis and sharp appendicitis; a purpose is z''yasuvati features of pathogeny of immune and citokinovoy dizregulyacii at sharp appendicitis and abdominal tuberculosis.;iaoiae - imunofermentniy (determination of concentration of interleykiniv - 1, 2, 6, 8, 10, factor of necrosis of pukhlin); populyaciynogo to composition limfocitiv of peripheral blood, concentration of immunoproteins of A, G, M, circulatory immune complexes, in the whey of blood, mathematical (processing of the got data with the use dispersible and cross-correlation regressive mathematically statistical to the analysis); results - in the first time on the basis of complex estimation of parameters of cellular, gumoral'nogo immunity, citokinovogo status, comparison of displays of immune dizregulyacii is conducted for patients with abdominal tuberculosis (chronic specific inflammation) and sharp appendicitis (sharp heterospecific inflammatory process); in the first time it is rotined that changes citokinovogo and immune status depend on as an inflammatory process in an abdominal region; general lines at sharp appendicitis and abdominal tuberculosis is activating of gumoral'noy and kilernoy lanok of immunity, T-cellular immunodeficit, and differences consist in a display at sharp appendicitis of neutrophilic type of gemogrami, growth of content of Il-1, Il-6, Il-8, TNF-, at that time as for abdominal tuberculosis characteristic is a limfocitarniy type of gemogrami but more expressed increase of content of Il-2 and Il-10, that is foundation for differential diagnostics of these pathosiss; the estimation of consequences of imunoprovokaciynoy test of Koch determinations is improved immune and to citokinovogo status of patients to to and after leadthrough of test; it is rotined that after the changes of immune status and citokinovogo spectrum of blood the imunoprovokaciyna test of Koch sharpens the displays of abdominal tuberculosis; in the first time found out the presence of cross-correlation links different degree of closeness and direction between the levels of interleykiniv and by the indexes of cellular and gumoral'nogo immunity at both investigational pathosiss and predominance of their amount is rotined at the terms of abdominal tuberculosis by comparison to sharp appendicitis.