Sklyarov P. The role of gastrin in the regulation of excretion of the biologic active substances in the large intestine mucosa

Object – mechanisms of regulation of the synthesis, eduction and action of biologically active substances in the mucosa of the colon under the influence of gastrin; purpose – to establish the role of gastrin in the regulation of Nitrogen Oxide/NO-synthase and PGE2/COG-2 systems, lipid peroxidation, antioxidant enzymes activity in protecting the mucosa of the colon; methods - physiological, biochemical, morphological, statistical; the results - the role of gastrin in the regulation of Nitrogen Oxide/NO-synthase and PGE2/ cyclooxygenase-2 systems, lipid peroxidation, antioxidant enzymes activity and its influence on the condition of epithelyocytes of the colon are established. The determination of the gastrin level in blood and blockage of CCK-2 receptors in hypergastrinemia may be used for the diagnosis and treatment of the neoplasms of the large intestine; branch – medicine.