Ignatov D. Functional heterogeneity of neutrophils and its role in mechanisms of the regulation of human peripheral blood leukocyte counts

Object - the regulation of amount and form composition of human peripheral blood leucocytes. Purpose - to find out the role of neutrophil functional heterogeneity and lymphocyte apoptosis in the regulation mechanisms of amount of the human peripheral blood leucocytes. Methods - cytological, cytochemical, pH-metry, statistical. Results - cleared up the role of neutrophil functional heterogeneity and lymphocyte apoptosis in the mechanisms of organism nonspecific defense and in the regulation of form composition of peripheral blood leucocytes. Novelty - it is found out two groups of neutrophils: killers, which show the most ability to generate the active forms of oxygen, to adhesion to substrate and inactivate in result, and cagers, which less intensively generate the active forms of oxygen and does not adhesion to substrate. The results of research have been introduced in the education process of physiology department of Lugansk State Medical University, in the scientific work of Research Institute of Family Medical Problems and Research Laboratory of Clinical and Applied Neurophysiology of the Physiology Department of Donetsk National Medical University. Branch - medicine (normal physiology).