Zlotat O. The mechanism of the development of the hepatorenal syndrome in to the polyuric stage of sublimate nephropathy.

Object - early mechanisms the pathogenesis of the hepatorenal a syndrome; the purpose - to find out early mechanisms of development of the hepatorenal a syndrome into the polyuric a stage of sublimate nephropathy with development of ways of correction of this disease; methods - experimental; physiological; biochemical; statistical; results - the dissertation has investigated the pathogenesis of the hepatorenal syndrome as a basis of a deterioration of the course of renal and hepatic failure under the conditions of the polyuric stage of sublimate nephropathy . Et has been established that the pathogenesis of the development of secondary oliguria into the polyuric stage of sublimate nephropathy is due to a reperfusion injury of the proximal portion of the nephron in particular the S3- segments with an abatemend of the enzymatic fibrinolytic activity of the renal papilla due to the development of urothrombosis of the tubular lumen of the nephron . Secondary damage of the proximal and distat tubules at the expense of realizing the reperfusion "no-reflow" syndrome causes the establishment of positive correlations of relative water reabsorption with the proximal and distal reabsorptions of sodium ions . The polyuric stage of sublimate nephropathy is characherized by damage of the 3d functional site , of the hepatic lobule with phenomena of vacuolar degeneration , an inhibition of the activity of succinate dehydrogenase and a dilatation of the lumen of the central vein . The GA-40 medication under the conditions of the development of the hepatorenal syndrome in case of the polyuric stage of sublimate nephropathy exerts a protective effect that is manifested in the restoration of the activity of succinate dehydrogenase in Cortex I , Cortex II - the subcapsular and juxtamedullary areas of the cortical substance of the kidneys the 3d functional site of the hepatic lobule a decrease of the degree of the hydropic degeneration of nephrocytes and hepatocytes .