Semenenko S. Pathophysiological mechanisms of disturbances of the chronorhythmic organization of the renal functions under the conditions of monooxide nitrogen blocking against a background of pineal hypo- and hyperfunction

Object - chronorhythms the organization excretory, ion-regulating and acid-regulating function functions of kidneys under condition of blockade of synthesis NO and different duration of the photoperiod; the purpose - to establish interrelation between functional condition PG and synthesis NO, and also to define pathophysiological mechanisms of infringements chronorhythms the organizations organization excretory, ion-regulating and acid-regulating functions of kidneys; methods - chronobyological, biochemical, physiological, statistical, histologic; results - it has been established for the first time that NO is an important intracellular messenger of regulating chronorhythms of the excretory, ion-regulating and acid-regulating function of the kidneys$ it has been demonstrated that the effects of N?-nitro-L-arginine blocking (L-NNA) of NO synthesis depend on the functional activity of the PG; L-NNA blocking of NO synthesis under the conditions PG hypofunction results in more marked changes of the integral characteristics of chronorhythms of the principal parameters in the functional condition of the kidneys as compared with blocking NO synthesis with underlying PG hyperfunction; the use of melatonin brings about a correction of chronorhythmic rearrangements of the architectonics and phasic structure of rhythms of the majority of the parameters under study induced by blocking of NO synthesis. Introducing the NO L-NNA disturbs the morphology of pinealocytes and nephrocytes of rats under the conditions of permanent lighting; the administration of melatonin brings about a certain resolving action on the state of pinealocytes, and a decrease of the degree of dystrophy in the kidneys; the changes of quantitative parameters of the chronorhythms of the excretory, ion-regulating and acid-regulating functions of the kidneys determine the expediency of updating the methods of early diagnostics and preventing renal diseases.