Smetyuk O. Pathogenetic mechanisms of disorders of renal excretory function in patients with pulmonary tuberculosis according to the polymorphism of enzymes of xenobiotic metabolism

The thesis is devoted to clarify the role of gene polymorphisms glutathione-S-transferase M1 and T1 (GSTM1, GSTT1) and N-acetyltransferase NAT2 in the development of the pathophysiological mechanisms of disorders of renal excretory function in the application of the anti-tuberculosis therapy in patients with pulmonary tuberculosis, which is to define a set of laboratory and clinical criteria to help predict possible toxic nephropathy of varying severity depending on the gene polymorphisms of xenobiotic metabolism enzymes. It was shown the contribution of GSTM1 and NAT2 polymorphisms in possibility of developing chronic tuberculosis. It was found that the level of microalbuminuria was more sensitive indicator of changes in the kidney compared with proteinuria. It was established that the GSTT1 null-allele might be a risk factor for the defeat of basilar membranes of kidney glomeruli during the primary immune response to M.tuberculosis. There were presented results, which showed informative method LCS serum and urine in the evaluation of renal functional changes during tuberculosis infection.