Savka T. The role of nitric oxide in the regulation of absorption and secretion in colon under normal conditions and in ulcerative colitis

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0412U004849

Thesis Registration Form

0412U004849.pdf

Applicant for

Specialization

  • 14.03.03 - Нормальна фізіологія

23-11-2012

Specialized Academic Board

Д 35.600.03

Essay

The paper is devoted to the evaluation of the influence of nitric oxide and the blocker of NO-synthase L-NAME on the processes of water and electrolytes (Na+, K+, Cl-) transport in colon under normal conditions and in experimental colitis in rats. In control animals L-arginine inhibited the absorption of the ions Na+; L-NAME introduction caused the increase of Na+ ions absorption. L-arginine administration in colitis caused the reversion of Na+ ions absorption to the secretion. Introduction of L-NAME in colitis caused insignificant increase of Na+ absorption. Melanin (20 mg/kg) decreased the destructive damage, activity of lipoperoxidation processes and іNOS.

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