Anyuta S. Treatment and prevention of obstetric and perinatal complications in women with hypertension.

The dissertation id devoted to actual problem of modern obstetrics - frequency reduction of obstetrics and perinatal complications of pregnant women suffering from hypertension by the way of improving the complex of treatment and prevention measures on the base of studying new links of pathogeny (abnormality of vascular regulations). According to Doppler research the existence of endothelial dysfunction (predominance of hyperergic type of brachial artery reaction after occlusion), which is proved by researching the indices of condition of endothelial function (increasing the level of endothelin-1 and reduction - nitrogen oxide), system of prostanoids (increasing the level of thromboxane, reduction - prostacyclin). Established the reduction of protective action of angiopoietin-1 on vessel wall. Inflammatory immune injures endothelium of vessels (increasing the level of proinflammatory cytokine interleukin- 6 without increasing the level of controlling interleukin-2). By immunohistochemical research of placentas was established the weak level of expression and low propagating factor of adhesion of thrombocyte to endothelium CD31, indicating a lack of compensatory angiogenesis and the risk of thrombosis. Having improved medico-prophylactic measures for pregnant women suffering from hypertension and with the high risk of perinatal complications, aimed at eliminating endothelial dysfunction and abnormality of vessel regulations.