Onyshchuk Y. Excessive Doses of Alcohol as Risk Factor in Acute Coronary Syndrome Developing

Object of study - acute coronary syndrome and excessive amounts of alcohol. Purpose - determine the impact of excessive doses of alcohol on the development of ACS and the the clinical course of MI and NA functional performance of the heart (ECG, echocardiography), changes in biochemical and immunological blood parameters, and ultrastructural remodeling and platelet infarction, to improve the prevention and diagnosis of coronary artery disease.For the first time found that in patients with ACS who consumed excessive amounts of alcohol, preferably no peredinfarktna typical angina and no pain, there is a tendency to arrhythmias (atrial fibrillation and ventricular, supraventricular tachycardia, ventricular extrasystoles), transient QT prolongation and blockade bundle branch block.It is found that under the influence of alcohol in some patients with ACS during hospitalization average QT interval was significantly higher than benchmarks that can cause life-threatening arrhythmias. At the 3-5-day corticosteroids duration of the QT interval returned to normal.Found that almost half of the patients who abused alcohol showed a reduction in the average total cholesterol and its fractions and atherogenic elevation of triglycerides.In patients with ACS who abused alcohol, signs of systemic inflammation, a manifestation of which is a significant increase in proinflammatory cytokines (TNF-a, sTNTR1, IL-1b, IL-16 and IL-8) and C-reactive protein, compared with controlled.It has been shown that patients with ACS who abused alcohol, revealed edema, degenerative changes of platelets and reduction of content a-and dense granules and accumulation of glycogen in the cytoplasm, indicating a decrease in their prokoahulyatsiynyh properties, but increased adhezyvnosti.It has been shown that alcohol causes the activation of apoptosis in endothelial microvascular bed and leads to significant myocardial microcirculation disorders, which contributes to ACS.It was found that excessive amounts of alcohol lead to damage of mitochondria in cardiomyocytes by establishing hibernation and fatty degeneration of cardiomyocytes and in the future - their apoptosis and focal necrosis. These structural changes are the basis for the emergence of corticosteroids in the presence or absence coronary sclerosis.The results are put into practice of medical institutions, scientific and educational process. Industry - medicine.