Tsevelev S. Mechanisms of control of pathologically increased excitability of the brain in conditions of influence of electromagnetic radiation of low intensity and extremely high frequency(experimental investigation)

The dissertation is dedicated to investigation of pathogenetic mechanisms of electromagnetic radiation of extremely high frequency on foci of epileptic activity in the brain cortex. Electromagnetic radiation of extremely high frequency and low intensity was found to have anti-seizure effect in the models of focal epileptic activity that were induced by applying of sodium salt of benzilpenicillin (10000 IU/ml) in the brain cortex of rats, as well as introduction of solutions of penicillin, kainic acid and strychnine in the hippocampus. It was determined that the immediate effect of electromagnetic radiation of extremely high frequency on the foci was dependant on their intensity. The most relatively significant effect was found in 15-minute exposition. Anti-seizure effect of electromagnetic radiation of extremely high frequency was shown in models of acute generalized epileptic activity, induced with intraventricular introduction of solutions of sodium benzilpenicillin (1000 IU) and kainate acid (10 mkg). Electromagnetic radiation of extremely high frequency was shown to increase the anti-seizure effect of diazepam on focal and generalized forms of epileptic syndrome. Anti-seizure effect of electromagnetic radiation of extremely high frequency was found in the model of corazol-induced kindling, as well as its effect concerning the behavioral impairments between attacks.