Leskiv K. Pharmacological correction of the antioxidant and immune system of intact pigs and under condition of chronic nitrate and nitrite toxicosis

The subject: antioxidant system, lipid peroxidation, immune system, an experimental chronic nitrate-nitrite toxicosis of pigs. Objective research: investigate the influence of fenaron, methionine and comprehensive applications in the form of drug metifen on biochemical and morphological parameters of blood intact piglets at 90 days of age. Explore the features of immune and antioxidant systems of pigs in conditions of chronic nitrate-nitrite toxicity. Test methods: pharmacological, toxicological, clinical, physiological, biochemical, biometrics. Scientific innovation: set new biochemical and immunological patterns in the development of HNNT in pigs, the features of AOS and lipid peroxidation in pigs, found a direct correlation between the level of nitrates in the feed pigs and the concentration of lipid peroxidation products (lipid hydroperoxides, diene conjugates) and an inverse relationship between the level of of feed and enzyme activity of AOS in pigs body. Determined dependence on the state of lipid peroxidation processes AOS and their role in the development of HNNT in piglets. Degree of implementation: Based on the research results developed patent for useful model № 65511 Ukraine, IPC (2011.01) A01K 67/00, G01N 33/48 (2006/01) Method of assessing the degree of nitrite impact on the body of pigs. Manufacture proposals laid out in methodic recommeddations: the prevention of chronic nitrate-nitrite toxicos in pigs recommended to use: fenaron in a dose - 1.20 mg / kg bw; metifen - 0.9 mg / kg bw, and methionine in a dose - 4 mg / kg bw. : Application field: veterinary medicine.