Savinа A. Morphological adaptation mechanisms of the liver in acute pancreatitis (an experimental study).

The thesis addressed pressing problem - the study of morphological and functional adaptation / disadaptative liver and portal venous system in acute pancreatitis. Used modeling of acute pancreatitis, which included the introduction of the pancreas ethanol 0.3 ml and 0.3 ml of saline alone or in combination with crushing its parenchyma. The animals of the control and experimental groups in the modeling of experimental acute pancreatitis is a qualitative and quantitative changes in indicators of portal hemodynamics: uvelichevalsya portal vein diameter, decreased linear and volumetric blood flow in the portal vein. Can increase the rate of volume flow rate to 100 g of body weight, the vibrations of which depended on the change in the diameter of portal vein and the animal's weight. Index of portal blood flow in the animals of the experimental group throughout the experiment went down below the reference data, which pointed to the development of processes in the liver decompensation with a decrease in its functional reserve. Found that morphological adaptation mechanisms of the liver to acute pancreatitis were aimed at reducing the toxicity of the enzyme, which was followed by hydration of the hepatic parenchyma with venous plethora body. Elevated levels of total water. These protective mechanisms provoking compression edematous tissue walled blood vessels (sinusoidal capillaries), which was accompanied by hypoxia gistotaksicheskoy in violation of the functional state of the hepatocytes. As evidenced by the increase in liver exposure sorption dynamics. The degree of liver disease and portal hemodynamic changes were dependent on the modeling of acute pancreatitis and the exposure experiment. With increasing exposure experiment morphological changes in the liver were more pronounced.