Lytvynova S. The pathogenic role of proteinases and inhibitors of proteinases in development of pathology in female reproductive system

A research object is mechanisms of the woman reproductive system pathology development; purpose - to establish the pathogenetic importance of local heterospecific proteinase and their inhibitors in the mechanisms of the woman reproductive system pathological processes development; methods - biochemical, biological, morphological, instrumental and statistical; novelty and results - the regional characteristics of heterospecific proteinase activity and their inhibitors are established by complex study of proteolysis processes in the cervical-vaginal, uterine lavage and follicle liquid for women reproductive system different pathology; in the cervical-vaginal lavage heterospecific proteinase activity is high, and inhibitors activity is minimum; in the uterine lavage inhibitors activity increase, but proteinase activity decrease; in a follicle liquid inhibitors level higher with minimum proteolytic enzymes activity; in the cervical-vaginal lavage proteinase-inhibitor systems disturbances are registered, they depend of age and at presence of infertility; the increase of woman age and pre- and postmenopausal period are accompanied the increase of elastaselike and tripsinlike activity of the cervical-vaginal lavage and the decrease of natively synthesized proteinase acid-resistant inhibitors (ARI) level; for infertility women the significant increase of ARI level and decrease of antitrypsin level activity is detected as compared to these rates for healthy women; the proteinase-inhibitor system condition in the cervical-vaginal secret with vagina biocenosis disturbances is studied; a proteinase-inhibitor system components disbalance is develops, most express with vaginitis formation, and it express degree depends of the cervical-vaginal secret leukocytic infiltration and bacterial semination level; inflammatory process markers comparative characteristic is analyzed at endometrium hyperplasia (EH); more severe EH form is accompanied inflammatory changes express increase, which manifest the proteinase activity increase, inhibitors level decrease, proinflammatory cytokines level increase in the uterine lavage and CD45+ express increase in endometrium; it is introduced - in the educational process of the S. I. Georgievsky Crimean state medical university, M. Gorky Donetsk national medical university, Kharkov national medical university, Ukrainian medical stomatological academy, Zaporozhia state medical university, Odessa national medical university, Ivano-Francovsk national medical university, N I. Pirogov Winnitca national medical university pathological physiology departments; use field is scientific and pedagogical processes of medical educational institutions pathological physiology and histology departments, obstetrics and gynecology departments treatment-and-diagnostic process, laboratories and diagnostic centers.