Dеsyatsky V. Pathophysiologycal mechanisms of pathologically enhanced excitation of brain under conditions of modulation of nitrogen oxide system activity (experimental investigation)

Thesis is devoted to pathophysiological mechanisms of epileptic syndrome establishment. In the investigation on the model of corazol-induced kindling it was established that L-NAME intensified while L-arginine abolished absence manifestations which are observed at the early stage of kindling formation. Mentioned effects have been substituted on opposite ones in rats with fully developed kindled seizures. L-arginin alleviated the painful reactions of rats which were investigated during postseizure depressive period, and induced increase of thiol groups level in the blood, especially of those not-protein originated. Also L-arginine induced investigative behavior of rats in open field test and suppressed the aggressive reactions as well as restored locomotions in swimming test and abolished kindling-induced deteriorations of sleep-wakefulness cycle. L-NAME blocked while L-arginine intensified antiepileptic effects of bacterial lypopolysaccharide on the manifestations of focal epileptic activity which was induced by sodium benzyl penicillin, kainic acid, bicuculline and strychnine administrations.