Mirovich K. Clinics and pathogenetics of substantiation neofasciogenesis at women with cystocele and rectocele

The dissertation is devoted to a substantiation of application of synthetic materials with the purpose of decrease in quantity of relapses at the patients of group of risk of their occurrence after surgical treatment cyctocele and rectocele. In work on the basis of the retrospective clinical-statistical analysis of the remote results of surgical treatment genital prolapse it is shown, that frequency of relapses of disease in 82,5 % of cases is connected with infringements from facial pelvic structures used for reconstruction of normal interposition organs of pelvis. Thus dependence of occurrence of relapses on the risk factors testifying about presence insufficiency of conjunctive tissue, caused by dystrophic changes or presence system dysplasia of conjunctive tissue is established. On the basis of definition of the importance of the allocated factors the mathematical model of calculation of individual risk of development of relapses of disease after its surgical treatment is developed. Objectivity of prognosis data received as a result construction of mathematical model, has been confirmed by research of morphological features of a structure and exchange processes of a conjunctive tissue at the patients carried in group of risk. Application of methods neofasciogenesis in surgical treatment cystocele and rectocele at such patients allows to lower frequency of relapses in 4,3 times in comparison with the methods based on use own structures of conjunctive tissue. At the same time, routine use of the given methods is inexpedient in connection with essential complication of operative intervention and presence of high risk intro-and postoperative complications.